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Primary Immunodeficiency Diseases Market’s Global Surge: 2025-2033 Players


 Report Overview

The global Primary Immunodeficiency Diseases Market was valued at US$ 7.3 billion in 2023 and is projected to attain US$ 13.0 billion by 2031, with a CAGR of 7.6% spanning 2024-2031.

This progression is attributed to higher PID diagnoses, immunoglobulin therapy advancements, and gene editing breakthroughs.

The Primary Immunodeficiency Diseases Market includes replacement therapies, stem cell transplants, and biologics for over 300 rare disorders.

North America holds sway with 43.3% share, bolstered by diagnostic innovations.

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Key Highlights

  • Market Growth: The global Primary Immunodeficiency Diseases Market is forecasted to grow from US$ 7.3 billion in 2023 to US$ 13.0 billion by 2031 at a CAGR of 7.6%.

  • North America Dominance: 43.3% share, led by U.S. prevalence in antibody deficiencies.

  • Ig Replacement Lead: 56.6% segment share via IVIG and SCIG modalities.

  • Diagnostic Advances: Sequencing tools uncover 70% undiagnosed cases.

  • Key Focus Areas: Antibody and cellular immunodeficiencies drive therapeutic needs.

  • Prominent Companies: CSL Behring and Grifols pioneer plasma-derived solutions.

Market Dynamics

Drivers: Prevalence and Tech Progress

The Primary Immunodeficiency Diseases Market expands with 6 million global cases, 86.1% incidence rise recently.

Immunoglobulin use surges 19%, with 24.3% of patients on replacement therapy.

Gene therapies and biologics target inflammation, improving outcomes.

Awareness campaigns and newborn screening enhance early detection rates.

Restraints: Treatment Barriers

Elevated costs, often $50,000+ yearly for IVIG, strain healthcare systems.

Skilled specialist shortages delay accurate PID diagnoses.

Low awareness in rural areas leaves 70% cases undetected.

Supply chain issues for plasma products cause intermittent shortages.

Segmentation Analysis

By Disease Type

The Primary Immunodeficiency Diseases Market segments into antibody, cellular, innate immune disorders, and others.

Antibody deficiencies, like IgA, prevail at 63.4% with selective impacts.

Cellular types, including Wiskott-Aldrich, require specialized transplants.

Innate disorders grow via TLR deficiency research.

By Treatment

Treatments encompass Ig replacement (56.6%), stem cell transplantation, gene therapy, and others.

SCIG offers home-based convenience over IVIG.

Gene editing emerges for monogenic PIDs.

Supportive antibiotics complement core therapies.

By End-User

End-users include hospitals, specialty clinics, research centers, and others, with hospitals foremost.

Specialty clinics specialize in infusion protocols.

Academic centers advance trial-based innovations.

Home care expands for subcutaneous administrations.

Geographical Analysis

North America: Premier Market

North America leads the Primary Immunodeficiency Diseases Market at 43.3%, with 16.4% U.S. IgA prevalence.

Advanced immunology hubs facilitate 27% IVIG growth.

55.7% male patient focus informs targeted R&D.

Policy support covers high-cost therapies comprehensively.

Other Regions

Asia-Pacific accelerates as fastest grower, with rising diagnostics in China.

Europe harmonizes treatments via EMA approvals.

South America builds via Brazil's screening programs.

Middle East & Africa tackle via international aid initiatives.

Major Companies

  • CSL Behring

  • Grifols

  • Biotest AG

  • Abbott Laboratories

  • Pfizer

  • AstraZeneca

  • Baxter International, Inc.

  • Bayer

  • Bristol Myers Squibb

  • Eli Lilly

Recent Developments

  • 2022: Pfizer's Panzgya gained FDA nod for PID immunotherapy.

  • September 2023: Abbott acquired Bigfoot for integrated care expansion.

  • August 2022: CSL Behring bought Vifor to bolster therapeutics.

  • March 2023: Gene therapy trials advanced for severe combined immunodeficiency.

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Report Scope

Metrics

  • CAGR: 7.6%

  • Market Size Available: 2022-2031

  • Forecast Period: 2024-2031

  • Revenue Units: US$ Billion

Segmentation

  • Disease Type: Antibody, Cellular, Innate, Others

  • Treatment: Ig Replacement, Stem Cell, Gene Therapy, Others

  • End-User: Hospitals, Clinics, Research Centers, Others

About DataM Intelligence

DataM Intelligence 4Market Research delivers elite syndicated and customized reports in biotechnology, healthcare, and pharmaceuticals.

Our statistical depth and strategic insights catalyze market leadership.

Committed to excellence, we empower global enterprises with reliable intelligence.

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